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Associate Prof. Zahari P. Vinarov, Ph.D., Ph.D in Pharm (Head of the department)
CV | Publications | Image Representation | Phone: +359 2 8161 416

Zahari P. Vinarov, Associate Prof

Research interests:

Oral delivery of poorly water-soluble drugs
Lipid digestion
Chemical analysis
Enzymes in Detergency and Digestion
Wetting, Contact Angles, Optical Microscopy
» See papers and citations at Google Scholar.
» ResearcherID (Web of Science): K-7184-2012
» Author ID (SCOPUS): 55233825500
» ORCID: 0000-0003-1857-1840




1. Enzymatic Prodrug Degradation in The Fasted and Fed Small Intestine: In vitro Studies and Interindividual Variability in Human Aspirates. Z. Vinarov, C. Tistaert, J. Bevernage, H. Bohets, Int. J. Pharm. 649 (2024). doi: 10.1016/j.ijpharm.2023.123654



1. Cholesterol Solubilization: Interplay between Phytosterols, Saponins and Lipid Digestion Products. S. Tsibranska-Gyoreva, V. Petkov, V. Katev, D. Krastev, Z. Vinarov, S. Tcholakova, Colloids Surf. A 662 (2023) 131052. doi: 10.1016/j.colsurfa.2023.131052

2. Assessment of Food Effects During Clinical Development. Z. Vinarov, J. Butler, F. Kesisoglou, M. Koziolek, P. Augustijns, Int. J. Pharm. 635 (2023) 122758. doi: 10.1016/j.ijpharm.2023.122758

3. Characterization of Neonatal And Infant Enterostomy Fluids - Part II: Drug Solubility. T. de Waal, J. Brouwers, M. Rayyan, C. Stillhart, L. Vinarova, Z. Vinarov, P. Augustijns, Int. J. Pharm. 642 (2023) 123141. doi: 10.1016/j.ijpharm.2023.123141

4. Voices in Molecular Pharmaceutics: Meet Dr. Zahari Vinarov, Who Unites Physical Chemistry and Pharmacy to Tackle Fundamental and Industrial Biopharmaceutical Challenges. Z. Vinarov, Mol. Pharm. (2023). doi: 10.1021/acs.molpharmaceut.3c00820

5. Прилагане на физикохимични подходи за решаване на фундаментални и индустриални предизвикателства пред Фармацията. З. Винаров, сп. „Българска Наука“, брой 171, стр. 57-61 [научно-популярна статия]



1. Best Practices in Current Models Mimicking Drug Permeability in The Gastrointestinal Tract - An UNGAP Review.. J. O'Shea, P. Augustijns, M. Brandl, D. Brayden, J. Brouwers, B. Griffin, R. Holm, A. Jacobsen, H. Lennernäs, Z. Vinarov, C.O'Driscoll, Eur. J. Pharm. Sci. 170 (2022) 106098; doi: 10.1016/j.ejps.2021.106098

2. Interplay between bulk aggregates, surface properties and foam stability of nonionic surfactants.. F. Mustan, N. Politova-Brinkova, Z. Vinarov, D. Rossetti, P. Rayment, S. Tcholakova, Adv. Colloid Interface Sci. 302 (2022) 102618; doi: 10.1016/j.cis.2022.102618

3. Self-Emulsification in Chemical and Pharmaceutical Technologies. D. Cholakova, Z. Vinarov, S. Tcholakova, N. Denkov, Current Opinion in Colloid & Interface Sci. 59 (2022) 101576; doi: 10.1016/j.cocis.2022.101576 [arXiv]



1. Mechanisms of Drug Solubilization by Polar Lipids in Biorelevant Media, V. Katev, Z. Vinarov, S. Tcholakova, Eur. J. Pharm. Sci. 159 (2021) 105733; doi: 10.1016/j.ejps.2021.105733

2. Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network, Z. Vinarov, B. Abrahamsson, P. Artursson, H. Batchelor, P. Berben, A. Bernkop-Schnürch, J. Butler, J. Ceulemans, N. Davies, D. Dupont, G. Flaten, N. Fotaki, B. Griffinn, V. Jannin, J. Keeminki, F. Kesisoglou, M. Koziolek, M. Kuentz, A. Mackie, A. Meléndez-Martinez, M. McAllister, A. Müllertz, C. O'Driscoll, N. Parrott, J. Paszkowska, P. Pavek, C. Porter, C. Reppas, C. Stillhart, K. Sugano, E. Toader, K. Valentová, M. Vertzoni, S. De Wildt, C. Wilson, P. Augustijns, Adv. Drug. Deliv. Rev. 171 (2021) 289–331; doi: 10.1016/j.addr.2021.02.001

3. Impact of Gastrointestinal Tract Variability on Oral Drug Absorption and Pharmacokinetics: An UNGAP Review, Z. Vinarov, M. Abdallah, J. Agundez, K. Allegaert, A. Basit, M. Braeckmans, J. Ceulemans, M. Corsetti, B. Griffin, M. Grimm, D. Keszthelyi, M. Koziolek, C. Madla, C. Matthys, L. McCoubrey, A. Mitra, C. Reppas, J. Stappaerts, N. Steenackers, N. Trevaskis, T. Vanuytsel, M. Vertzoni, W. Weitschies, C. Wilson, P. Augustijns, Eur. J. Pharm. Sci. 162 (2021) 105812; doi: 10.1016/j.ejps.2021.105812

4. Supersaturation and Solubilization upon In Vitro Digestion of Fenofibrate Type I Lipid Formulations: Effect of Droplet Size, Surfactant Concentration and Lipid Type, V. Katev, S. Tsibranska-Gyoreva, Z. Vinarov, S. Tcholakova, Pharmaceutics 13 (2021) 1287; doi: 10.3390/pharmaceutics13081287



1. Role of Lysophospholipids on The Interfacial and Liquid Film Properties of Enzymatically Modified Egg Yolk Solutions. D. Gazolu-Rusanova, F. Mustan, Z. Vinarov, S. Tcholakova, N. Denkov, S. Stoyanov, J. W.J. de Folter, Food Hydrocolloids 99 (2020) 105319; doi: 10.1016/j.foodhyd.2019.105319

2. Solubilization of Itraconazole by Surfactants and Phospholipid-Surfactant Mixtures: Interplay of Amphiphile Structure, pH and Electrostatic Interactions. Z. Vinarov, G. Gancheva, N. Burdzhiev, S. Tcholakova, J. Drug Deliv. Sci. Technol. 57 (2020) 101688; doi: 10.1016/j.jddst.2020.101688



1. Successful Oral Delivery of Poorly Water-soluble Drugs Both Depends on The Intraluminal Behavior of Drugs and of Appropriate Advanced Drug Delivery Systems. B. J. Boyd, C. A.S. Bergström, Z. Vinarov, M. Kuentz, J. Brouwers, P. Augustijns, M. Brandl, A. Bernkop-Schnürch, N. Shrestha, V. Préat, A. Müllertz, A. Bauer-Brandl, V. Jannin, Eur. J. Pharm. Sci. 137 (2019); doi: 10.1016/j.ejps.2019.104967



1. Effect of Surfactant Molecular Structure on Progesterone Solubilization. Z. Vinarov, P. Dobreva, S. Tcholakova. J. Drug. Deliv. Sci. Tec., 43 (2018) 44–49; doi: 10.1016/j.jddst.2017.09.014

2. Micellar Solubilization of Poorly Water-soluble Drugs: Effect of Surfactant and Solubilizate Molecular Structure. Z. Vinarov, V. Katev, D. Radeva, S. Tcholakova, N. Denkov. Drug. Dev. Ind. Pharm., 44 (2018) 677–686 doi: 10.1080/03639045.2017.1408642

3. Albendazole Solution Formulation via Vesicle-To-Micelle Transition of Phospholipid-Surfactant Aggregates. Z. Vinarov, G. Gancheva, V. Katev, S. Tcholakova, in Drug. Dev. Ind. Pharm. (2018) doi: 10.1080/03639045.2018.1438461

4. Effect of Surfactant–Bile Interactions on the Solubility of Hydrophobic Drugs in Biorelevant Dissolution Media. Z. Vinarov, V. Katev, N. Burdzhiev, S. Tcholakova, N. Denkov, Mol. Pharm. 15 (2018) 5741−5753 doi: 10.1021/acs.molpharmaceut.8b00884



1. Efficient Self-Emulsification via Cooling-Heating Cycles. S. Tcholakova, Z. Valkova, D. Cholakova, Z. Vinarov, I. Lesov, N. D. Denkov, K. Smoukov. Nature Comm., 8 (2017) 15012; doi: 10.1038/ncomms15012



1. Mechanism of Lowering Cholesterol Absorption by Calcium Studied by In Vitro Digestion Model. L. Vinarova, Z. Vinarov, S. Tcholakova, N. D. Denkov, S. Stoyanov, A. Lips. Food & Function 7 (2016) 151–163.

2. Improving Ibuprofen Solubility by Surfactant-Facilitated Self-Assembly into Mixed Micelles. K. Stoyanova, Z. Vinarov, S. Tcholakova. J. Drug. Deliv. Sci. Tec. 36 (2016) 208–215.



1. Lowering of Cholesterol Bioaccessibility and Serum Concentrations by Saponins: in Vitro and in Vivo Studies. L. Vinarova, Z. Vinarov, V. Atanasov, I. Pantcheva, S. Tcholakova, N. Denkov, S. Stoyanov. Food & Function 6 (2015) 501–512.

2. Mechanisms of Cholesterol and Saturated Fatty Acid Lowering by Quillaja saponaria Extract, Studied by in vitro Digestion Model. L. Vinarova, Z. Vinarov, B. Damyanova, S. Tcholakova, N. Denkov, S. Stoyanov. Food & Function 6 (2015) 1319–1330.



1. Ice cream: A delicious mix of crystals, droplets and bubbles. Z. Vinarov, BBC Knowledge (Bulgaria), 43 (2013) 28-33. [in Bulgarian, popular science]



1. Effects of Emulsifier Charge and Concentration on Pancreatic Lipolysis. 1. In the Absence of Bile Saltsd. Z. Vinarov, Y. Petkova, S. Tcholakova, N. Denkov, S. Stoyanov, E. Pelan, A Lips, Langmuir 28 (2012) 8127-8139.

2. Effects of Emulsifier Charge and Concentration on Pancreatic Lipolysis: 2. Interplay of Emulsifiers and Biles. Z. Vinarov, S. Tcholakova, B. Damyanova, Y. Atanasov, N. Denkov, S. Stoyanov, E. Pelan, A. Lips, Langmuir 28 (2012) 12140-12150.

3. In vitro study of triglyceride lipolysis and phase distribution of the reaction products and cholesterol: effects of calcium and bicarbonate. Z. Vinarov, L. Petrova, S. Tcholakova, N. Denkov, S. Stoyanov, A. Lips, Food & Function 3 (2012) 1206-1220.

4. Role of calcium in the battle against "bad" cholesterol. Z. Vinarov, BBC Knowledge (Bulgaria) (2012) 36 64-69. [in Bulgarian, popular science]