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Biopharmaceutical Tools and Drug Formulation Technologies



1. Mechanisms of Drug Solubilization by Polar Lipids in Biorelevant Media, V. Katev, Z. Vinarov, S. Tcholakova, Eur. J. Pharm. Sci. 159 (2021) 105733; doi: 10.1016/j.ejps.2021.105733

2. Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network, Z. Vinarov, B. Abrahamsson, P. Artursson, H. Batchelor, P. Berben, A. Bernkop-Schnürch, J. Butler, J. Ceulemans, N. Davies, D. Dupont, G. Flaten, N. Fotaki, B. Griffinn, V. Jannin, J. Keeminki, F. Kesisoglou, M. Koziolek, M. Kuentz, A. Mackie, A. Meléndez-Martinez, M. McAllister, A. Müllertz, C. O'Driscoll, N. Parrott, J. Paszkowska, P. Pavek, C. Porter, C. Reppas, C. Stillhart, K. Sugano, E. Toader, K. Valentová, M. Vertzoni, S. De Wildt, C. Wilson, P. Augustijns, Adv. Drug. Deliv. Rev. 171 (2021) 289–331; doi: 10.1016/j.addr.2021.02.001

3. WIPO Patent: Oil-in-Water Emulsion of Nano-Sized Self-Emulsified Particulates, N. Denkov, S. Tcholakova, D. Glushkova, D. Cholakova, S. Smoukov, Patent Number: WO 2020/260577A1/ 30.12.2020

4. Impact of Gastrointestinal Tract Variability on Oral Drug Absorption and Pharmacokinetics: An UNGAP Review, Z. Vinarov, M. Abdallah, J. Agundez, K. Allegaert, A. Basit, M. Braeckmans, J. Ceulemans, M. Corsetti, B. Griffin, M. Grimm, D. Keszthelyi, M. Koziolek, C. Madla, C. Matthys, L. McCoubrey, A. Mitra, C. Reppas, J. Stappaerts, N. Steenackers, N. Trevaskis, T. Vanuytsel, M. Vertzoni, W. Weitschies, C. Wilson, P. Augustijns, Eur. J. Pharm. Sci. 162 (2021) 105812; doi: 10.1016/j.ejps.2021.105812



1. Solubilization of Itraconazole by Surfactants and Phospholipid-Surfactant Mixtures: Interplay of Amphiphile Structure, pH and Electrostatic Interactions. Z. Vinarov, G. Gancheva, N. Burdzhiev, S. Tcholakova, J. Drug Deliv. Sci. Technol. 57 (2020) 101688; doi: 10.1016/j.jddst.2020.101688



1. Successful Oral Delivery of Poorly Water-soluble Drugs Both Depends on The Intraluminal Behavior of Drugs and of Appropriate Advanced Drug Delivery Systems. B. J. Boyd, C. A.S. Bergström, Z. Vinarov, M. Kuentz, J. Brouwers, P. Augustijns, M. Brandl, A. Bernkop-Schnürch, N. Shrestha, V. Préat, A. Müllertz, A. Bauer-Brandl, V. Jannin, Eur. J. Pharm. Sci. 137 (2019); doi: 10.1016/j.ejps.2019.104967



1. Effect of Surfactant Molecular Structure on Progesterone Solubilization. Z. Vinarov, P. Dobreva, S. Tcholakova. J. Drug. Deliv. Sci. Tec., 43 (2018) 44–49; doi: 10.1016/j.jddst.2017.09.014

2. Micellar Solubilization of Poorly Water-soluble Drugs: Effect of Surfactant and Solubilizate Molecular Structure. Z. Vinarov, V. Katev, D. Radeva, S. Tcholakova, N. Denkov. Drug. Dev. Ind. Pharm., 44 (2018) 677–686 doi: 10.1080/03639045.2017.1408642

3. Albendazole Solution Formulation via Vesicle-To-Micelle Transition of Phospholipid-Surfactant Aggregates. Z. Vinarov, G. Gancheva, V. Katev, S. Tcholakova, in Drug. Dev. Ind. Pharm. (2018) doi: 10.1080/03639045.2018.1438461

4. Effect of Surfactant–Bile Interactions on the Solubility of Hydrophobic Drugs in Biorelevant Dissolution Media. Z. Vinarov, V. Katev, N. Burdzhiev, S. Tcholakova, N. Denkov, Mol. Pharm. 15 (2018) 5741−5753 doi: 10.1021/acs.molpharmaceut.8b00884



1. Mechanism of Lowering Cholesterol Absorption by Calcium Studied by In Vitro Digestion Model. L. Vinarova, Z. Vinarov, S. Tcholakova, N. D. Denkov, S. Stoyanov, A. Lips. Food & Function 7 (2016) 151–163.

2. Improving Ibuprofen Solubility by Surfactant-Facilitated Self-Assembly into Mixed Micelles. K. Stoyanova, Z. Vinarov, S. Tcholakova. J. Drug. Deliv. Sci. Tec. 36 (2016) 208–215.



1. Lowering of Cholesterol Bioaccessibility and Serum Concentrations by Saponins: in Vitro and in Vivo Studies. L. Vinarova, Z. Vinarov, V. Atanasov, I. Pantcheva, S. Tcholakova, N. Denkov, S. Stoyanov. Food & Function 6 (2015) 501–512.

2. Mechanisms of Cholesterol and Saturated Fatty Acid Lowering by Quillaja saponaria Extract, Studied by in vitro Digestion Model. L. Vinarova, Z. Vinarov, B. Damyanova, S. Tcholakova, N. Denkov, S. Stoyanov. Food & Function 6 (2015) 1319–1330.



1. Effects of Emulsifier Charge and Concentration on Pancreatic Lipolysis. 1. In the Absence of Bile Saltsd. Z. Vinarov, Y. Petkova, S. Tcholakova, N. Denkov, S. Stoyanov, E. Pelan, A Lips, Langmuir 28 (2012) 8127-8139.

2. Effects of Emulsifier Charge and Concentration on Pancreatic Lipolysis: 2. Interplay of Emulsifiers and Biles. Z. Vinarov, S. Tcholakova, B. Damyanova, Y. Atanasov, N. Denkov, S. Stoyanov, E. Pelan, A. Lips, Langmuir 28 (2012) 12140-12150.

3. In vitro study of triglyceride lipolysis and phase distribution of the reaction products and cholesterol: effects of calcium and bicarbonate. Z. Vinarov, L. Petrova, S. Tcholakova, N. Denkov, S. Stoyanov, A. Lips, Food & Function 3 (2012) 1206-1220.